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Hypochlorous Acid - A Breakthrough Natural Topical for Eczema Sufferers!

Eczema Patient Using Hypochlorous Acid

By Dr. Diane Angela Fong, ND

Eczema, a chronic skin condition characterized by red, itchy, and inflamed skin, affects millions worldwide. While various treatments exist, a revolutionary approach has emerged in recent years—Hypochlorous Acid (HOCl). This naturally occurring substance has garnered attention for its potential in rebalancing the skin microbiome and alleviating eczema symptoms. In this article, we explore the science behind HOCl and its application in managing eczema.

Understanding Hypochlorous Acid:

Hypochlorous Acid is a weak acid that the human body produces as a defense mechanism against pathogens. It is part of the innate immune response and acts as a powerful antimicrobial agent. The comprehensive review by Natarelli et al. (2022) delves into the diverse applications of HOCl in dermatology, providing a comprehensive overview of its antimicrobial, anti-inflammatory, and antipruritic properties.

  1. Antimicrobial Properties: HOCl exerts its antimicrobial effects through oxidative stress. It selectively targets and disrupts the cell membranes of bacteria, viruses, and fungi, leading to microbial inactivation. This mechanism helps to eliminate harmful microorganisms on the skin, contributing to the reduction of infections and the restoration of a healthier skin microbiome.

  2. Antipruritic Effects: Fukuyama et al. (2017) elucidate that HOCl possesses antipruritic properties, meaning it alleviates itching associated with eczema. This effect is attributed to HOCl's ability to modulate sensory nerve fibers and inhibit the release of pruritogenic (itch-inducing) mediators. By reducing itching, HOCl aids in improving the quality of life for individuals with eczema.

  3. Anti-Inflammatory Actions: The anti-inflammatory effects of HOCl contribute significantly to its efficacy in managing eczema. Studies, including Fukuyama et al. (2017) and Natarelli et al. (2022), suggest that HOCl suppresses inflammatory pathways and cytokine release, mitigating the inflammatory response seen in eczematous skin. This anti-inflammatory action helps in reducing redness, swelling, and discomfort associated with eczema flare-ups.

Restoring the Skin Microbiome:

Eczema is linked to disruptions in the skin microbiome, the diverse community of microorganisms inhabiting our skin. The antipruritic, anti-inflammatory, and antimicrobial properties of HOCl collectively contribute to rebalancing the skin microbiome, creating an environment conducive to healthier skin.

Clinical Evidence:

Building upon this foundation of the first study by Fukuyama et al. (2017), a subsequent study by Fukuyama et al. (2018) conducted a comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model. The results demonstrated the efficacy of HOCl in reducing eczema symptoms, reinforcing its potential as a valuable addition to eczema management.

My Clinical Experience:

In my clinical practice, I have used Hypochlorous Acid successfully as part of a topical regimen to lower inflammation, guard against skin infections, and lower itching. All of these positive effects allow the patient's skin to begin the healing process, while we work on healing the internal organs to address the root cause.

Safety and Tolerance:

One of the key advantages of HOCl is its safety profile. Being a naturally occurring substance in the body, it is well-tolerated and unlikely to cause adverse reactions. This is particularly beneficial for individuals with sensitive skin, a common characteristic of those with eczema.

Application and Usage:

HOCl-based formulations, as seen in these studies and reviewed by Natarelli et al. (2022), are available in various forms, including sprays, creams, and wipes. These products can be incorporated into daily skincare routines, providing a practical and convenient means of managing eczema. Consultation with our Cleanbody Team is recommended to determine the most suitable application for individual cases.

Hypochlorous Acid stands at the forefront of innovative eczema care, offering a targeted and safe approach to address skin microbiome imbalances. While further research is warranted, existing evidence from studies such as Fukuyama et al. (2017, 2018), the comprehensive review by Natarelli et al. (2022), and my clinical experience suggest that HOCl holds great promise in revolutionizing eczema management. As with any medical intervention, consulting with healthcare professionals is crucial for personalized and effective treatment. Purchase our CleanSKIN Kit, which includes CleanSKIN Calm, a hypochlorous acid product to address irritated skin.


  1. Fukuyama T, Martel BC, Linder KE, Ehling S, Ganchingco JR, Bäumer W. "Hypochlorous Acid is Antipruritic and Anti-inflammatory in a Mouse Model of Atopic Dermatitis." Clinical and Experimental Allergy, 2017, doi: 10.1111/cea.13045.

  2. Fukuyama T, Ehling S, Wilzopolski J, Bäumer W. "Comparison of Topical Tofacitinib and 0.1% Hypochlorous Acid in a Murine Atopic Dermatitis Model." BMC Pharmacology and Toxicology, vol. 19, no. 1, 2018, p. 37. doi: 10.1186/s40360-018-0232-3. PMID: 29970189; PMCID: PMC6029395.

  3. Natarelli, Nicole, Yvonne Nong, Jessica Maloh, and Raja Sivamani. "Hypochlorous Acid: Applications in Dermatology." Journal of Integrative Dermatology, 2022.

Medical Disclaimer: The information provided in this blog post is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.



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